Compositions for intravenous treatment of genito-urinary infections and essential hypertension



Patented May 10, 1949 fiabienco ran Calif.

in Drawing. Application July 17, 1944, Serial No. 545,388

2 Claims. (Cl. 167-65) My invention relates to compositions for intravenous treatment of genito-urinary infections and essential hypertension, particularly cystitis, pyelitis and pyelonephritis or nephrosis; and its objects are to alleviate or correct by chemotherapy such disorders without resort to the technique of cystoscopic practice; to stimulate the kidneys to excrete and throw off poisons causing hypertension, and, without deleterious effects upon the patient, to restore to normalcy such diseased kidneys and the impaired pelvis of the kidney, together with the proper functioning of the ureter, bladder and urethra; to produce a beneficial therapeutic bactericidal effect without irritability to the genito-urinary tract, and at the same time to reduce essential hypertension when the composition is given intravenously in sterile solution and in the proper dosage, and to produce and restore a normal chemical balance in the human body without general reaction and Without the necessity of hospitalization.

My invention consists in forming a liquid compound for intravenous injections by bringing together methenamine (urotropin) and hydrochloric acid in predetermined proportions dissolved in triple distilled water and sterilized, to which may be added a small quantity of thiamin chloride (vitamin 3-1 or vitamin B-plex preferably in the form Beta syn plex, manufactured by the Winthrop Chemical Company, Inc., New York city, N. Y., and acting as a tonic and further remedial effect). It is preferably so put up that thirty grains of urotropin in five cubic centimeters of sterile Water solution is neutralized by five cubic centimeters of dilute hydrochloric acid (1-1000). For a range of weight of individuals from thirty to sixty kilos, or even more, I have found that the amount of required dosage may remain the same and will produce the same results; and so far as age is concerned, I have administered the drug to patients from eighteen to ninety-two years of age with excellent effects. Also I have found that patients afflicted with hypertrophied prostatic gland respond well to my form of chemotherapy.

I have found by experimentation, that when these two ingredients are properly combined in the right proportions of each, forming methenamine hydrochloride, the resulting compound in travenously administered will give the least irritability to the delicate mucous membrane of the genito-urinary tract and produces a desired bactericidal effect, and at the same time acts to reduce essential hypertension.

In administering my improved compound, I have discovered that while the same may be made in the preferred proportions above set forth, beneficial results will nevertheless be obtained when the ingredients are brought together in the following proportions:

30 grains of urotropin in 5 cc. of H20, with 10 cc. of hydrochloric 1-1000 to an ampule, to which may be added 900 to 3000 I U vitamin B-l per cc. of solution, or 1 to 10 milligrams vitamin B- plex.

The physiological action of my improved compound is twofold: (1) it acts as a kidney stimulant, causing the kidneys to excrete poisonous products which accumulate in the human body; and (2) it produces chemical balance in the body and thus acts to relieve hypertension and hypotension. The treatment is administered according to existing needs. If the patient is sufiering from acute cystitis the chemotherapy is given twice a day for two or three days. Then one injection is administered three times a week until fifteen injections are given. A few patients need to have more than fifteen injections, but none less. In hypertension, one treatment should be given every other day until the full course of fifteen injections has been taken. Individuals showing high diastolic pressure require longer treatments.

My invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiment, as above set forth, is therefore to be considered in all respects as illustrative and not restrictive, the scope of my invention being indicated by the appended claims rather than by the foregoing description, and all changes which may come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

What I claim and desire to secure by Letters Patent is: I

1. A liquid composition for intravenous injections containing ingredients in the approximate proportion of 30 grains of urotropin dissolved in about 5 cc. of water, and from 5 to 10 cc. of

hydrochloric acid oi! a concentration of about one Number Name Date part per thousand by weight. r 1,626,562 Silten Apr. 26, 1927 2. A liquid composition for intravenous inj 1,775,133 Larson Sept. 9, 1930 tion, including urotropin to which is added aqueous hydrochloric acid in sufflcient amount 0 5 FOREIGN PATENTS efleot acidification to an approximate pH in t e range of 6.7 to 6.9, but insuflicient to set free any gg g gsggg i i substantial amount of formaldehyde or ammonia. 1003727 Austria Aug 1925 AXENTIE T. BABIENCO.

10 OTHER REFERENCES REFERENCES CITED Anna Ratter, Ann. Chim. Applicata, vol. 29, The following references are of record in the pages 221-5 (1939).

file of this patent: Cecil, Textbook of Medicine, 5th edition, UNITED STATES PATENTS 15 figgigiders Co., Philadelphia, 1941, pages 1054 to Number Name Date Sallmann, Manual Pharmacology, 6th edition, 869,636 Mankiewicz t 1907 Saunders Co., Phila., 1942, pages 106, 682 to 685. 6 ,2 i er e 1 Hatcher, Useful Drugs, 13th edition, A. M. A.,

Chicago 1942, pages 160 and 161. 

